Successful Experiment with a Type 1 Diabetes Drug
Rio de Janeiro, (Xinhua) –A Brazilian study successfully tested the use of the active ingredient Sitagliptin, a DPP-4 inhibitor, in patients with Type 1 Diabetes, and demonstrated that this medicine can help improve Hemoglobin A1c levels, i.e., improve blood glucose levels control in people with Type 1 Diabetes, reported the state news agency Agencia Brasil. Sitagliptin is a DPP-4 inhibitor and is used as a Type 2 Diabetes drug; this study showed that people with Type 1 Diabetes can improve their blood sugar and Hemoglobin A1c levels when taking it in conjunction with their usual insulin treatment. Participants of this study were also part of another scientific study conducted by researchers from Sao Paulo, Brazil and Chicago, United States, which involved an autologous adult stem cells transplant.
By Joe Cardozo
According to the official Brazilian agency, the experiment is being conducted by researchers from the Faculty of Medicine of the University of Sao Paulo (USP) and already allowed at least two patients, who also simultaneously participated in another stem cells study, to stop their daily insulin injections, which are necessary in patients with this type of Diabetes to control their blood glucose levels.
Sitagliptin is a new drug that has been successfully used in people with Type 2 Diabetes, in which the patient has deficient insulin production and is typical in overweight adults who have high blood pressure and a sedentary lifestyle.
This is the first time that this drug has been tested in patients with Type 1 Diabetes, which usually develops in childhood and in which the patient’s pancreatic cells have stopped producing insulin because the body’s immune system has destroyed them.
“Sitagliptin causes insulin producing pancreatic cells to proliferate, even preventing glucagon action, which is the rival hormone of insulin,” said endocrinologist Carlos Eduardo Couri, one of the project authors, explaining why this medicine wasn’t usually recommended for patients with Type 1 Diabetes.
“Patients with type 1 Diabetes need insulin injections several times a day to not die,” said the specialist, who estimates that 5 percent of people with diabetes in Brazil have this type of Diabetes.
Couri explained that tests with Sitagliptin started on last February with two patients of a group of 23 volunteers from a stem cell therapy test (autologous hematopoietic adult stem cells) to treat Type 1 Diabetes.
This stem cell treatment is part of an experience that began in 2003 and which has been tested in patients around the world, including Brazil.
Stem cell therapy allowed for the suspension of insulin injections in 20 of the 23 patients for a certain time. Currently 14 of these patients have stopped using insulin for about two years.
However two of these patients who stopped taking insulin for some time, needed daily insulin injections again.
This is why the Brazilian researchers decided to experiment with Sitagliptin on those patients, managing to re-suspend their daily insulin injections.
According to Couri, after two months of using this medicine, these two patients no longer needed insulin. The initial success led researchers to increase the number of patients being treated with Sitagliptin.
“And all of these patients with Type 1 Diabetes, who are also volunteers in studies with stem cells, have had their daily applied insulin doses reduced. They take both two drugs simultaneously and as time goes by we notice they need less and less insulin”, said Couri.
“We don’t know what will happen with these patients in ten years. Nothing is guaranteed and, to not create false expectations, we can only allow patients from this experiment, who are volunteers, to take the medicine,” he added.
Diabetes Up to Date is full of hope due to this new discovery
At Diabetes Up to Date we are very pleased with optimism and hope due to the results of this new discovery, which brings us closer to a possible scientific cure for Type 1 Diabetes.
At Diabetes Up to Date we want to warn you to be careful of not falling into the trap of many unscrupulous individuals and companies, who take advantage of these difficult circumstances, to offer false cures or magic potions in the promise that Diabetes will disappear. Those who fall victim to these frauds, usually abandon their usual treatment, which causes severe irreversible damage to the body, leading to pain and suffering, when the only thing that’s actually improving are the bank accounts of these health merchants. Therefore, at Diabetes Up to Date we only inform you about facts from scientific studies done by accredited medical institutions and published by the most prestigious medical journals.
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